399 Innate immunity of keratynocytes in localized scleroderma

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Localized Scleroderma

Morphea (localized scleroderma) is an autoimmune disease characterized by sclerosis of the skin and, in some cases, subcutaneous tissue. It occurs in children and adults. It is distinct from systemic sclerosis, but may nevertheless be associated with significant functional and cosmetic impairment. Morphea has several distinct subtypes, including circumscribed, linear, and generalized, all of wh...

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PUVA therapy in localized scleroderma.

To the Editor: We report the case of an 80-yearold man with localized scleroderma, treated successfully with PUVA therapy. The patient came to our office with progressive hardening of his abdominal skin. Clinical examination (Fig. 1) showed a large (25 cm in diameter) slightly erythematous plaque that could not be pinched and made it difficult for the patient to bend down. The lesion margins we...

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the effects of high non fibrous carbohydrates diet on milk production, inflammation and molecular mechanism of innate immunity in lactating dairy cows

پژوهش حاضر با هدف بررسی اثر جیره حاوی کربوهیدراتهای غیرالیافی زیاد و بروز التهاب در گاوهای شیرده در دو آزمایش جداگانه انجام شد. در آزمایش اول 20 رأس گاو مبتلا به ورم پستان از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) و 20 رأس گاو سالم از دو گروه کم تولید و پرتولید (هر کدام 10 رأس) انتخاب شدند. همه گاوها در دوره دوم و یا سوم شیردهی و در روزهای 80-120 پس از زایش بودند. میانگین تولید شیر در گروه...

Surgical Management of Localized Scleroderma

BACKGROUND Localized scleroderma is characterized by a thickening of the skin from excessive collagen deposits. It is not a fatal disease, but quality of life can be adversely affected due to changes in skin appearance, joint contractures, and, rarely, serious deformities of the face and extremities. We present six cases of localized scleroderma in face from our surgical practice. METHODS We ...

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Mycophenolate mofetil for localized scleroderma

Commentary Systemic sclerosis is one of the rheumatic diseases that is associated with the worst prognosis. Systemic sclerosis is divided into localized and systemic forms. Localized scleroderma comprises four subtypes, namely morphea, generalized morphea, linear scleroderma and en coup de saber, and is more commonly encountered in children. Although conversion into systemic sclerosis is very u...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2016

ISSN: 0022-202X

DOI: 10.1016/j.jid.2016.06.419